Automatic extraction of recurrent patterns of high dominant frequency mapping during human persistent atrial fibrillation

Li, X., Chu, G.S., Almeida, T.P., Vanheusden, F. ORCID: 0000-0003-2369-6189, Salinet, J., Dastagir, N., Mistry, A.R., Vali, Z., Sidhu, B., Stafford, P.J., Schlindwein, F.S. and Ng, G.A., 2021. Automatic extraction of recurrent patterns of high dominant frequency mapping during human persistent atrial fibrillation. Frontiers in Physiology, 12: 649486. ISSN 1664-042X

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Abstract

Purpose: Identifying targets for catheter ablation remains challenging in persistent atrial fibrillation (persAF). The dominant frequency (DF) of atrial electrograms during atrial fibrillation (AF) is believed to primarily reflect local activation. Highest DF (HDF) might be responsible for the initiation and perpetuation of persAF. However, the spatiotemporal behaviour of DF remains not fully understood. Some DFs during persAF were shown to lack spatiotemporal stability, while others exhibit recurrent behaviour. We sought to develop a tool to automatically detect recurrent DF patterns in persAF patients.

Methods: Non-contact mapping of the left atrium (LA) was performed in 10 patients undergoing persAF HDF ablation. 2048 virtual electrograms (vEGMs, EnSite Array, Abbott Laboratories, USA) were collected for up to 5 min before and after ablation. Frequency spectrum was estimated using fast Fourier transform and DF was identified as the peak between 4-10 Hz and organization index (OI) was calculated. The HDF maps were identified per 4-second window and an automated pattern recognition algorithm was used to find recurring HDF spatial patterns. Dominant patterns (DPs) were defined as the HDF pattern with the highest recurrence.

Results: DPs were found in all patients. Patients in atrial flutter after ablation had a single DP over the recorded time period. The time interval (median [IQR]) of DP recurrence for the patients in AF after ablation (7 patients) decreased from 21.1 s [11.8 49.7s] to 15.7 s [6.5 18.2 s]. The DF inside the DPs presented lower temporal standard deviation (0.18±0.06 Hz vs. 0.29±0.12 Hz, p<0.05) and higher OI (0.35±0.03 vs. 0.31±0.04, p<0.05). The atrial regions with the highest proportion of HDF region were the septum and the left upper pulmonary vein.

Conclusion: Multiple recurrent spatiotemporal HDF patterns exist during persAF. The proposed method can identify and quantify the spatiotemporal repetition of the HDFs, where the high recurrences of DP may suggest a more organised rhythm. DPs presented a more consistent DF and higher organisation compared with non-DPs, suggesting that DF with higher OI might be more likely to recur. Recurring patterns offer a more comprehensive dynamic insight of persAF behaviour, and ablation targeting such regions may be beneficial.

Item Type: Journal article
Publication Title: Frontiers in Physiology
Creators: Li, X., Chu, G.S., Almeida, T.P., Vanheusden, F., Salinet, J., Dastagir, N., Mistry, A.R., Vali, Z., Sidhu, B., Stafford, P.J., Schlindwein, F.S. and Ng, G.A.
Publisher: Frontiers Media
Date: 12 March 2021
Volume: 12
ISSN: 1664-042X
Identifiers:
NumberType
10.3389/fphys.2021.649486DOI
1410111Other
Rights: © 2021 Li, Chu, Almeida, Vanheusden, Salinet, Dastagir, Mistry, Vali, Sidhu, Stafford, Schlindwein and Ng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 24 Feb 2021 15:56
Last Modified: 26 Jul 2021 09:37
URI: http://irep.ntu.ac.uk/id/eprint/42370

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