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Al-Musharaf, S., Sabico, S., Hussain, S.D., Al-Tawashi, F., AlWaily, H.B., Al-Daghri, N.M. and McTernan, P. 
ORCID: 0000-0001-9023-0261,
2021.
Inflammatory and adipokine status from early to midpregnancy in arab women and its associations with gestational diabetes mellitus.
Disease Markers, 2021: 8862494.
ISSN 0278-0240
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Abstract
Objective. To examine differences in maternal serum levels of adipokines (adiponectin, leptin, and resistin) and inflammatory markers (tumor necrosis factor-alpha (TNF-α) and interlukin-6 (IL-6)) from early to midpregnancy among Arab women with or without gestational diabetes mellitus (GDM), along with their links to GDM risk.
Methods. This is a multicenter prospective study involving 232 Saudi women attending obstetric care. Both circulating adipokine and markers of inflammation were observed at the first (eight to 12 weeks) and second trimesters (24 to 28 weeks). GDM was screened at 24 to 28 weeks using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria.
Results. Age and body mass index- (BMI-) matched circulating TNF-α was significantly higher in women with GDM in comparison to non-GDM women (). Adiponectin and resistin significantly decreased from the first to second trimester in women without GDM ( and 0.026, respectively). Leptin presented a significant rise from the first to second trimester in both groups, with a higher increase in women with GDM (). Multivariate logistic regression analysis revealed that TNF-α was significantly correlated with GDM (). However, significance was lost after adjustments for maternal and lifestyle risk factors (OR 23.58 (0.50 to 1119.98), ).
Conclusion. Inflammatory and adipocytokine profiles are altered in Arab women with GDM, TNF-α in particular. Further studies are needed to establish whether maternal inflammatory and adipocytokine profile influence fetal levels in the same manner.
| Item Type: | Journal article | ||||||
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| Publication Title: | Disease Markers | ||||||
| Creators: | Al-Musharaf, S., Sabico, S., Hussain, S.D., Al-Tawashi, F., AlWaily, H.B., Al-Daghri, N.M. and McTernan, P. | ||||||
| Publisher: | Hindawi Limited | ||||||
| Date: | 23 January 2021 | ||||||
| Volume: | 2021 | ||||||
| ISSN: | 0278-0240 | ||||||
| Identifiers: |
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| Rights: | Copyright © 2021 Sara Al-Musharaf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 25 Feb 2021 12:08 | ||||||
| Last Modified: | 31 May 2021 15:06 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/42389 |
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