Impairments in glycaemic control do not increase linearly with repeated nights of sleep restriction in healthy adults: a randomized controlled trial

Sweeney, E.L. ORCID: 0000-0002-6946-2989, Peart, D.J., Ellis, J.G. and Walshe, I.H., 2021. Impairments in glycaemic control do not increase linearly with repeated nights of sleep restriction in healthy adults: a randomized controlled trial. Applied Physiology, Nutrition, and Metabolism. ISSN 1715-5312

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Abstract

Evidence suggests reduced glycaemic control following sleep restriction in healthy individuals. However, it remains unknown if impairments in glycaemic control increase with each additional night of sleep restriction in a linear manner. This randomised crossover study aimed to determine if the impairment in glycaemic control increases with each additional night of sleep restriction. Ten healthy individuals underwent four nights of control sleep (eight hours in bed) and four nights of sleep restriction (four hours in bed) in a sleep laboratory. An oral glucose tolerance test was conducted each morning. Serum glucose and insulin were measured. Glucose and insulin area under the curve were higher overall in the sleep restriction trial compared to control (p < 0.001 and p = 0.033), however no effect of day (p = 0.620 and p = 0.863) or interaction effect (p = 0.152 and p = 0.285) were observed. This supports previous literature showing a detrimental impact of sleep restriction on glucose regulation. The present findings, however, suggest the impairment in glycaemic control does not increase in a linear manner with an increasing number of nights of sleep restriction. This may have implications for the design of future studies examining sleep restriction and glycaemic control.

Item Type: Journal article
Publication Title: Applied Physiology, Nutrition, and Metabolism
Creators: Sweeney, E.L., Peart, D.J., Ellis, J.G. and Walshe, I.H.
Publisher: Canadian Science Publishing
Date: 15 March 2021
ISSN: 1715-5312
Identifiers:
NumberType
10.1139/apnm-2020-1025DOI
1426459Other
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 18 Mar 2021 17:51
Last Modified: 31 May 2021 15:05
URI: http://irep.ntu.ac.uk/id/eprint/42542

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