Effectiveness of various sintering aids on the densification and in vitro properties of carbonated hydroxyapatite porous scaffolds produced by foam replication technique

Syazwan, M.N.M., Ahmad-Fauzi, M.N., Balestri, W., Reinwald, Y. ORCID: 0000-0001-6733-605X and Marliana, B.I.Y., 2021. Effectiveness of various sintering aids on the densification and in vitro properties of carbonated hydroxyapatite porous scaffolds produced by foam replication technique. Materials Today Communications, 27: 102395. ISSN 2352-4928

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Abstract

Synthetic carbonated hydroxyapatite (CHA) ceramics are considered as future materials for bone substitutes due to their good bioactivity, biocompatibility and similarity to the inorganic mineralized phase of bone. However, the limited thermal stability of CHA-based materials at elevated temperature remains a critical challenge particularly in producing three-dimensional (3D) porous scaffolds. To address the aforementioned limitation, this paper presents a new approach by incorporating several types of sintering aids, namely Mg(OH)2, Ca(OH)2, NaOH, KOH and K2CO3 into the CHA slurry composition to identify the most effective ones in developing 3D CHA scaffolds. This approach focused on physico-chemical, mechanical and biological characteristics that can be helpful in designing scaffolds for bone tissue engineering. Five compositions of scaffolds were prepared by replication technique, sintered at 800°C and eventually cooled down in wet CO2 atmosphere. Scaffolds prepared with K2CO3 (CHAKC) as sintering aid exhibited optimum interconnected pores with densified struts and the highest compressive strength. Biologically, CHAKC provides the most favorable milieu in supporting apatite formation as well as encouraging better cell attachment and activities. Our findings highlight that the use of K2CO3 had effectively enhanced the architecture and compressive strength of the CHA scaffolds without any toxicity evidence.

Item Type: Journal article
Publication Title: Materials Today Communications
Creators: Syazwan, M.N.M., Ahmad-Fauzi, M.N., Balestri, W., Reinwald, Y. and Marliana, B.I.Y.
Publisher: Elsevier
Date: June 2021
Volume: 27
ISSN: 2352-4928
Identifiers:
NumberType
10.1016/j.mtcomm.2021.102395DOI
S2352492821003871Publisher Item Identifier
1436020Other
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 05 May 2021 14:23
Last Modified: 14 Jun 2021 08:11
URI: http://irep.ntu.ac.uk/id/eprint/42819

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