The antimicrobial activity of silver acetate against Acinetobacter baumannii in a Galleria mellonella infection model

Mannix-Fisher, E. and McLean, S. ORCID: 0000-0001-8551-4307, 2021. The antimicrobial activity of silver acetate against Acinetobacter baumannii in a Galleria mellonella infection model. PeerJ, 9: e11196. ISSN 2167-8359

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Abstract

Background: The increasing prevalence of bacterial infections that are resistant to antibiotic treatment has caused the scientific and medical communities to look for alternate remedies aimed at prevention and treatment. In addition to researching novel antimicrobials, there has also been much interest in revisiting some of the earliest therapies used by man. One such antimicrobial is silver; its use stretches back to the ancient Greeks but interest in its medicinal properties has increased in recent years due to the rise in antibiotic resistance. Currently antimicrobial silver is found in everything from lunch boxes to medical device implants. Though much is claimed about the antimicrobial efficacy of silver salts the research in this area is mixed.

Methods: Herein we investigated the efficacy of silver acetate against a carbapenem resistant strain of Acinetobacter baumannii to determine the in vitro activity of this silver salt against a World Health Organisation designated category I critical pathogen. Furthermore, we use the Galleria mellonella larvae model to assess
toxicity of the compound and its efficacy in treating infections in a live host.

Results: We found that silver acetate can be delivered safely to Galleria at medically relevant and antimicrobial levels without detriment to the larvae and that administration of silver acetate to an infection model significantly improved survival. This demonstrates the selective toxicity of silver acetate for bacterial pathogens
but also highlights the need for administration of well-defined doses of the antimicrobial to provide an efficacious treatment.

Item Type: Journal article
Publication Title: PeerJ
Creators: Mannix-Fisher, E. and McLean, S.
Publisher: PeerJ
Date: 22 April 2021
Volume: 9
ISSN: 2167-8359
Identifiers:
NumberType
10.7717/peerj.11196DOI
1433869Other
Rights: © 2021 Mannix-Fisher and McLean. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 21 May 2021 09:59
Last Modified: 31 May 2021 15:02
Related URLs:
URI: http://irep.ntu.ac.uk/id/eprint/42903

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