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Templeman, I., Smith, H., Chowdhury, E., Chen, Y.C., Carroll, H., Johnson-Bonson, D., Hengist, A., Smith, R., Creighton, J., Clayton, D. 
ORCID: 0000-0001-5481-0891, Varley, I. ORCID: 0000-0002-3607-8921, Karagounis, L.G., Wilhelmsen, A., Tsintzas, K., Reeves, S., Walhin, J.P., Gonzalez, J.T., Thompson, D. and Betts, J.A.,
2021.
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults.
Science Translational Medicine, 13 (598): eabd8034.
ISSN 1946-6234
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1444715_a1711_Clayton.pdf - Post-print Download (1MB) | Preview |
Abstract
Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healthy individuals (0:150; n = 12). Control groups involved a matched degree of energy restriction applied continuously without fasting (75% energy intake daily; 75:75; n = 12) or a matched pattern of fasting without net energy restriction (200% energy intake on alternate days; 0:200; n = 12). Primary outcomes were body composition, components of energy balance, and postprandial metabolism. Daily energy restriction (75:75) reduced body mass (−1.91 ± 0.99 kilograms) almost entirely due to fat loss (−1.75 ± 0.79 kilograms). Restricting energy intake via fasting (0:150) also decreased body mass (−1.60 ± 1.06 kilograms; P = 0.46 versus 75:75) but with attenuated reductions in body fat (−0.74 ± 1.32 kilograms; P = 0.01 versus 75:75), whereas fasting without energy restriction (0:200) did not significantly reduce either body mass (−0.52 ± 1.09 kilograms; P ≤ 0.04 versus 75:75 and 0:150) or fat mass (−0.12 ± 0.68 kilograms; P ≤ 0.05 versus 75:75 and 0:150). Postprandial indices of cardiometabolic health and gut hormones, along with the expression of key genes in subcutaneous adipose tissue, were not statistically different between groups (P > 0.05). Alternate-day fasting less effectively reduces body fat mass than a matched degree of daily energy restriction and without evidence of fasting-specific effects on metabolic regulation or cardiovascular health.
| Item Type: | Journal article | ||||
|---|---|---|---|---|---|
| Alternative Title: | Interactive effects of fasting and energy restriction on energy balance and metabolic health: a randomized controlled trial in lean adults | ||||
| Publication Title: | Science Translational Medicine | ||||
| Creators: | Templeman, I., Smith, H., Chowdhury, E., Chen, Y.C., Carroll, H., Johnson-Bonson, D., Hengist, A., Smith, R., Creighton, J., Clayton, D., Varley, I., Karagounis, L.G., Wilhelmsen, A., Tsintzas, K., Reeves, S., Walhin, J.P., Gonzalez, J.T., Thompson, D. and Betts, J.A. | ||||
| Publisher: | American Association for the Advancement of Science | ||||
| Date: | 16 June 2021 | ||||
| Volume: | 13 | ||||
| Number: | 598 | ||||
| ISSN: | 1946-6234 | ||||
| Identifiers: |
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| Divisions: | Schools > School of Science and Technology | ||||
| Record created by: | Linda Sullivan | ||||
| Date Added: | 11 Jun 2021 13:34 | ||||
| Last Modified: | 21 Jun 2021 10:20 | ||||
| URI: | https://irep.ntu.ac.uk/id/eprint/43043 |
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