Enantioselective synthesis of five-membered-ring atropisomers with a chiral Rh(III) complex

Shaaban, S., Li, H., Otte, F., Strohmann, C., Antonchick, A.P. ORCID: 0000-0003-0435-9443 and Waldmann, H., 2020. Enantioselective synthesis of five-membered-ring atropisomers with a chiral Rh(III) complex. Organic Letters, 22 (23), pp. 9199-9202. ISSN 1523-7060

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Abstract

Axially chiral atropisomeric compounds are widely applied in asymmetric catalysis and medicinal chemistry, and efficient methods for their synthesis are in high demand. This applies in particular to atropisomers derived from five-membered aromatic rings because their lower barrier for rotation among the biaryl axis limits their asymmetric synthesis. We report here an enantioselective C–H functionalization method using our chiral RhJasCp complex for the synthesis of the biaryl atropisomer types that can be accessed from three different five-membered-ring heterocycles.

Item Type: Journal article
Publication Title: Organic Letters
Creators: Shaaban, S., Li, H., Otte, F., Strohmann, C., Antonchick, A.P. and Waldmann, H.
Publisher: American Chemical Society (ACS)
Date: 4 December 2020
Volume: 22
Number: 23
ISSN: 1523-7060
Identifiers:
NumberType
10.1021/acs.orglett.0c03355DOI
1447707Other
Rights: Copyright © 2020 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 23 Jun 2021 15:24
Last Modified: 23 Jun 2021 15:24
URI: http://irep.ntu.ac.uk/id/eprint/43173

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