The clinical value of monitoring gold levels in patients with rheumatoid arthritis undergoing chrysotherapy

Heath, M.J., 1988. The clinical value of monitoring gold levels in patients with rheumatoid arthritis undergoing chrysotherapy. PhD, Nottingham Trent University.

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Abstract

In this study of patients with rheumatoid arthritis undergoing chrysotherapy, good correlations were demonstrated between total, free and protein bound gold and between these parameters and salivary and urinary gold levels. The possibility of monitoring efficacy of toxicity of treatment was established using a combination of total and free serum gold levels in the form of ratios and correlation plots with regression. Circadian rhythmicity of urinary gold excretion was demonstrated and further relationships were demonstrated between urinary gold, zinc and copper excretion rates. Relationships were also shown between immunological proteins and complement and the various gold fractions in serum, saliva and urine. Although the differential binding of gold to various protein fractions was demonstrated, analysis of samples stored at different temperatures revealed different protein binding properties for gold at the different temperatures. Gold distribution amongst the protein fractions is too sensitive to changes in temperature to be used routinely to monitor treatment. Finally it was demonstrated that the gold and thiol moieties of disodium aurothiomalate have different fates following intramuscular injection for whilst free plasma thiomalate peaked between 30 and 45 minutes after injection and was no longer detected in urine after 4 hours, the gold reached a peak in plasma 60 to 120 minutes post injection and was still present in urine in significant amounts after 4 hours The urinary recovery of free thiomalate revealed that 82-98% of the injected thiol moiety remained in the body in some form following the clearance of the free plasma levels.

Item Type:	Thesis
Creators:	Heath, M.J.
Date:	1988
ISBN:	9781369325188
Identifiers:	Number Type PQ10290269 Other
Rights:	This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from T the thesis and no information derived from it may be published without the author's prior written consent.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	24 Jun 2021 11:24
Last Modified:	15 Nov 2023 15:27
URI:	https://irep.ntu.ac.uk/id/eprint/43210

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