Effect of menstrual cycle phase, menstrual irregularities and hormonal contraceptive use on anterior knee laxity and non-contact anterior cruciate ligament injury occurrence in women: a protocol for a systematic review and meta-analysis

Nédélec, E., Foli, E., Shultz, S.J., Swinton, P.A., Dolan, E., Enright, K., Piasecki, J. ORCID: 0000-0001-9758-6295, Matthews, J.J. ORCID: 0000-0002-0143-8341, Sale, C. ORCID: 0000-0002-5816-4169 and Elliott-Sale, K.J. ORCID: 0000-0003-1122-5099, 2021. Effect of menstrual cycle phase, menstrual irregularities and hormonal contraceptive use on anterior knee laxity and non-contact anterior cruciate ligament injury occurrence in women: a protocol for a systematic review and meta-analysis. BMJ Open Sport and Exercise Medicine, 7 (4): e001170. ISSN 2055-7647

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Abstract

Exercising women report three to six times more ACL tears than men, which happen, in the majority of cases, with a non-contact mechanism. This sex disparity has, in part, been attributed to the differences in reproductive hormone profiles between men and women. Many studies have shown that anterior knee (AK) laxity and the rate of non-contact ACL injuries vary across the menstrual cycle, but these data are inconsistent. Similarly, several studies have investigated the potential protective effect of hormonal contraceptives on non-contact ACL injuries, but their conclusions are also variable. The purpose of this systematic review and meta-analysis is to, identify, evaluate and summarise the effects of endogenous and exogenous ovarian hormones on AK laxity (primary outcome) and the occurrence of non-contact ACL injuries (secondary outcome) in women. We will perform a systematic search for all observational studies conducted on this topic. Studies will be retrieved by searching electronic databases, clinical trial registers, author’s personal files and cross-referencing selected studies. Risk of bias will be assessed using the Newcastle Ottawa Quality Assessment Scale for Cohort and Case–Control Studies. Certainty in the cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. The meta-analyses will use a Bayesian approach to address specific research questions in a more intuitive and probabilistic manner. This review is registered on the international database of prospectively registered systematic reviews (PROSPERO; CRD42021252365).

Item Type: Journal article
Publication Title: BMJ Open Sport and Exercise Medicine
Creators: Nédélec, E., Foli, E., Shultz, S.J., Swinton, P.A., Dolan, E., Enright, K., Piasecki, J., Matthews, J.J., Sale, C. and Elliott-Sale, K.J.
Publisher: BMJ Publishing Group
Date: 29 October 2021
Volume: 7
Number: 4
ISSN: 2055-7647
Identifiers:
NumberType
10.1136/bmjsem-2021-001170DOI
1485481Other
Rights: © Author(s) (or their employer(s)) 2021. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 08 Nov 2021 10:29
Last Modified: 08 Nov 2021 10:29
URI: http://irep.ntu.ac.uk/id/eprint/44642

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