Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: a vibro-acoustic analysis

Rostam-Alilou, A.A., Jafari, H., Zolfagharian, A., Serjouei, A. ORCID: 0000-0002-7250-4131 and Bodaghi, M. ORCID: 0000-0002-0707-944X, 2021. Using fibrincollagen composite hydrogel and silk for bio-inspired design of tympanic membrane grafts: a vibro-acoustic analysis. Composites Part C: Open Access, 6: 100205. ISSN 2666-6820

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Abstract

Tympanic membrane (TM) is vulnerable to a variety of middle ear diseases. In some cases, reconstruction or repair of the TM is essential for recovering the hearing. Although there are many kinds of materials and therapeutics for TM reconstruction, tissue engineering of the TM is still in its initial steps of advancement. Treatment of damaged TM is usually carried out by otology-related techniques such as myringoplasty and tympanoplasty. Most of the novel tympanoplasty methods employ artificial grafts made of biomaterials and polymers for scaffolds. One biomaterial candidate for design and fabrication of synthetic grafts is spider silk, which has excellent mechanical and acoustic characteristics. On the other hand, the structural function of the spider web is also one of the potential inspirations for designing tissue-engineered grafts on micro-scale explorations. In this study, a bio-inspired design and analysis of silky TM grafts are carried out employing finite element modeling and vibro-acoustic investigation. A comparative and statistical analysis is also performed with experimentally validated data to check the suitability of the materials and design. The numerical study shows that the proposed bio-inspired models are appropriate for TM graft design and fabrication. The effects of inspired architecture and materials on obtaining an optimum design for TM grafts are put into evidence via a parametric study, and pertinent conclusions are outlined.

Item Type: Journal article
Publication Title: Composites Part C: Open Access
Creators: Rostam-Alilou, A.A., Jafari, H., Zolfagharian, A., Serjouei, A. and Bodaghi, M.
Publisher: Elsevier BV
Date: October 2021
Volume: 6
ISSN: 2666-6820
Identifiers:
NumberType
10.1016/j.jcomc.2021.100205DOI
1492825Other
Rights: ©2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 17 Nov 2021 10:14
Last Modified: 17 Nov 2021 10:14
URI: http://irep.ntu.ac.uk/id/eprint/44840

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