Nanobugs as drugs: bacterial derived nanomagnets enhance tumor targeting and oncolytic activity of HSV‐1 virus

Howard, F.H.N., Al‐Janabi, H., Patel, P., Cox, K., Smith, E., Vadakekolathu, J. ORCID: 0000-0002-2671-4285, Pockley, A.G. ORCID: 0000-0001-9593-6431, Conner, J., Nohl, J.F., Allwood, D.A., Collado‐Rojas, C., Kennerley, A., Staniland, S. and Muthana, M., 2022. Nanobugs as drugs: bacterial derived nanomagnets enhance tumor targeting and oncolytic activity of HSV‐1 virus. Small: 2104763. ISSN 1613-6810

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Abstract

The survival strategies of infectious organisms have inspired many therapeutics over the years. Indeed the advent of oncolytic viruses (OVs) exploits the uncontrolled replication of cancer cells for production of their progeny resulting in a cancer-targeting treatment that leaves healthy cells unharmed. Their success against inaccessible tumors however, is highly variable due to inadequate tumor targeting following systemic administration. Coassembling herpes simplex virus (HSV1716) with biocompatible magnetic nanoparticles derived from magnetotactic bacteria enables tumor targeting from circulation with magnetic guidance, protects the virus against neutralizing antibodies and thereby enhances viral replication within tumors. This approach additionally enhances the intratumoral recruitment of activated immune cells, promotes antitumor immunity and immune cell death, thereby inducing tumor shrinkage and increasing survival in a syngeneic mouse model of breast cancer by 50%. Exploiting the properties of such a nanocarrier, rather than tropism of the virus, for active tumor targeting offers an exciting, novel approach for enhancing the bioavailability and treatment efficacy of tumor immunotherapies for disseminated neoplasms.

Item Type: Journal article
Publication Title: Small
Creators: Howard, F.H.N., Al‐Janabi, H., Patel, P., Cox, K., Smith, E., Vadakekolathu, J., Pockley, A.G., Conner, J., Nohl, J.F., Allwood, D.A., Collado‐Rojas, C., Kennerley, A., Staniland, S. and Muthana, M.
Publisher: Wiley
Date: 25 January 2022
ISSN: 1613-6810
Identifiers:
NumberType
10.1002/smll.202104763DOI
1511426Other
Rights: © 2022 the authors. Small published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 26 Jan 2022 15:57
Last Modified: 04 Feb 2022 16:19
URI: http://irep.ntu.ac.uk/id/eprint/45420

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