Influence of ternary divalent cations (Mg2+, Co2+, Sr2+) substitution on the physicochemical, mechanical and biological properties of carbonated hydroxyapatite scaffolds

Yanny Marliana, B.I., Muhammad Syazwan, M.N., Ahmad-Fauzi, M.N., Balestri, W. ORCID: 0000-0001-9111-8116 and Reinwald, Y. ORCID: 0000-0001-6733-605X, 2021. Influence of ternary divalent cations (Mg2+, Co2+, Sr2+) substitution on the physicochemical, mechanical and biological properties of carbonated hydroxyapatite scaffolds. Journal of the Australian Ceramic Society, 57 (5), 1499–1510. ISSN 2510-1560

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Abstract

Substitution of ionic either anion or cation in a controlled amount into carbonated hydroxyapatite (CHA) structure is one of the efficient and safest ways in enhancing the properties of the materials. However, most of the works studied only focused on the physical and mechanical properties of single ionic substitution. For the first time, the influence of simultaneous ternary substitutions of divalent cations into porous CHA scaffolds on the physicochemical, mechanical, degradation and in vitro biological properties are investigated in the present study. Three different compositions of porous scaffolds with binary and ternary divalent cations, namely, pure CHA (S11), CoSr CHA (S21) and MgCoSr CHA (S31) were fabricated using polyurethane (PU) foam replication technique. Despite a small amount of Mg 2+ , Co 2+ and Sr 2+ added, these divalent cations had successfully substituted into the Ca 2+ site and remained as single phase B-type CHA. The produced scaffolds demonstrated open, interconnected and uniform pores. Interestingly, simultaneous ternary divalent cations substitution into CHA structure had successfully enhanced the compressive strength of the sintered scaffolds, also promoted better cell attachment and activities than the binary doped-and pure CHA scaffolds. It is important to note that the right choice of divalent cation can be the determining factor in tuning the physicochemical, mechanical and biological properties of CHA scaffolds.

Item Type: Journal article
Publication Title: Journal of the Australian Ceramic Society
Creators: Yanny Marliana, B.I., Muhammad Syazwan, M.N., Ahmad-Fauzi, M.N., Balestri, W. and Reinwald, Y.
Publisher: Springer
Date: December 2021
Volume: 57
Number: 5
ISSN: 2510-1560
Identifiers:
NumberType
10.1007/s41779-021-00640-yDOI
1455408Other
Rights: Post-prints are subject to Springer Nature re-use terms
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 09 Feb 2022 10:58
Last Modified: 09 Feb 2022 10:58
URI: http://irep.ntu.ac.uk/id/eprint/45573

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