Controlled release of carnosine from poly(lactic-co-glycolic acid) beads using nanomechanical magnetic trigger towards the treatment of glioblastoma

Habra, K. ORCID: 0000-0001-8272-6048, Morris, R.H. ORCID: 0000-0001-5511-3457, Mcardle, S.E.B. ORCID: 0000-0001-6929-9782 and Cave, G.W.V. ORCID: 0000-0002-4167-1332, 2022. Controlled release of carnosine from poly(lactic-co-glycolic acid) beads using nanomechanical magnetic trigger towards the treatment of glioblastoma. Nanoscale Advances. ISSN 2516-0230

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Abstract

Nanometer scale rods of superparamagnetic iron oxide have been encapsulated, along with the anti-cancer therapeutic carnosine, inside porous poly(lactic-co-glycolic acid) microbeads with a uniform morphology, synthesised using microfluidic arrays. The sustained and externally triggered controlled release from these vehicles was demonstrated using a rotating Halbach magnet array, quantified via liquid chromatography, and imaged in situ using magnetic resonance imaging (MRI) and scanning electron microscopy (SEM). In the absence of the external magnetic trigger, the carnosine was found to be released from the polymer in a linear profile; however, over 50% of the drug could be released within 30 minutes of exposure to the rotating magnetic field. In addition, the release of carnosine embedded on the surface of the nano-rods was delayed if it was mixed with the iron oxide nano rods before the encapsulation. These new drug delivery vesicles have the potential to pave the way towards the safe and triggered release of onsite drug delivery, as part of a theragnostic treatment for glioblastoma.

Item Type: Journal article
Publication Title: Nanoscale Advances
Creators: Habra, K., Morris, R.H., Mcardle, S.E.B. and Cave, G.W.V.
Contributors:
NameRoleNTU IDORCID
Hickman, G.ContributorUNSPECIFIEDUNSPECIFIED
Boocock, D.ContributorUNSPECIFIEDUNSPECIFIED
Publisher: Royal Society of Chemistry
Date: 27 April 2022
ISSN: 2516-0230
Identifiers:
NumberType
10.1039/d2na00032fDOI
1542305Other
Rights: © 2022 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 29 Apr 2022 15:44
Last Modified: 29 Apr 2022 15:44
URI: http://irep.ntu.ac.uk/id/eprint/46226

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