Synthesis and biological investigation of 1,2,4-triazolo[4,3-a]azines as potential HSF1 inductors

Serebrennikova, P.O., Utepova, I.A., Chupakhin, O.N., Guzhova, I.V., Mikhaylova, E.R. and Antonchick, A.P. ORCID: 0000-0003-0435-9443, 2022. Synthesis and biological investigation of 1,2,4-triazolo[4,3-a]azines as potential HSF1 inductors. Synthesis. ISSN 0039-7881

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Abstract

Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation.

Item Type: Journal article
Publication Title: Synthesis
Creators: Serebrennikova, P.O., Utepova, I.A., Chupakhin, O.N., Guzhova, I.V., Mikhaylova, E.R. and Antonchick, A.P.
Publisher: Georg Thieme Verlag KG
Date: 17 March 2022
ISSN: 0039-7881
Identifiers:
NumberType
10.1055/s-0040-1719907DOI
1543235Other
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 05 May 2022 16:02
Last Modified: 05 May 2022 16:02
URI: http://irep.ntu.ac.uk/id/eprint/46274

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