Tools
Tools
Aladel, A., Murphy, A.M. 
ORCID: 0000-0001-5554-1558, Abraham, J., Shah, N., Barber, T.M., Ball, G. ORCID: 0000-0001-5828-7129, Menon, V., Piya, M.K. and McTernan, P.G. ORCID: 0000-0001-9023-0261,
2022.
Vitamin D levels as an important predictor for type 2 diabetes mellitus and weight regain post-sleeve gastrectomy.
Nutrients, 14 (10): 2052.
|
Text
1547642_McTernan.pdf - Published version Download (734kB) | Preview |
Abstract
Weight Loss Surgery (WLS), including sleeve-gastrectomy (SG), results in significant weight loss and improved metabolic health in severe obesity (BMI ≥ 35 kg/m2). Previous studies suggest post-operative health benefits are impacted by nutrient deficiencies, such as Vitamin D (25(OH)D) deficiency, while it is currently unknown whether nutrient levels may actually predict post-surgery outcomes. As such, this study investigated whether 25(OH)D levels could predict metabolic improvements in patients who underwent SG. Patients with severe obesity (n = 309; 75% female) undergoing SG participated in this ethics-approved, non-randomized retrospective cohort study. Anthropometry, clinical data, 25(OH)D levels and serum markers were collected at baseline, 6-, 12- and 18-months post-surgery. SG surgery resulted in significant improvements in metabolic health at 6- and 12-months post-surgery compared with baseline, as expected. Patients with higher baseline 25(OH)D had significantly lower HbA1c levels post-surgery (p < 0.01) and better post-surgical T2DM outcomes, including reduced weight regain (p < 0.05). Further analysis revealed that baseline 25(OH)D could predict HbA1c levels, weight regain and T2DM remission one-year post-surgery, accounting for 7.5% of HbA1c divergence (p < 0.01). These data highlight that higher circulating 25(OH)D levels are associated with significant metabolic health improvements post-surgery, notably, that such baseline levels are able to predict those who attain T2DM remission. This highlights the importance of 25(OH)D as a predictive biomarker of post-surgery benefits.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Alternative Title: | Vitamin D as predictor of metabolic outcomes | ||||||
| Publication Title: | Nutrients | ||||||
| Creators: | Aladel, A., Murphy, A.M., Abraham, J., Shah, N., Barber, T.M., Ball, G., Menon, V., Piya, M.K. and McTernan, P.G. | ||||||
| Publisher: | MDPI | ||||||
| Date: | 13 May 2022 | ||||||
| Volume: | 14 | ||||||
| Number: | 10 | ||||||
| Identifiers: |
|
||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 24 May 2022 10:18 | ||||||
| Last Modified: | 24 May 2022 10:18 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/46360 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
