The role of vascular-immune interactions in modulating chemotherapy induced neuropathic pain

Valentine, T., Hardowar, L., Elphick-Ross, J., Hulse, R.P. ORCID: 0000-0002-5193-9822 and Paul-Clark, M., 2022. The role of vascular-immune interactions in modulating chemotherapy induced neuropathic pain. Frontiers in Pharmacology, 13: 887608. ISSN 1663-9812

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Chemotherapy causes sensory disturbances in cancer patients that results in neuropathies and pain. As cancer survivorships has dramatically increased over the past 10 years, pain management of these patients is becoming clinically more important. Current analgesic strategies are mainly ineffective and long-term use is associated with severe side effects. The issue being that common analgesic strategies are based on ubiquitous pain mediator pathways, so when applied to clinically diverse neuropathic pain and neurological conditions, are unsuccessful. This is principally due to the lack of understanding of the driving forces that lead to chemotherapy induced neuropathies. It is well documented that chemotherapy causes sensory neurodegeneration through axonal atrophy and intraepidermal fibre degeneration causing alterations in pain perception. Despite the neuropathological alterations associated with chemotherapy-induced neuropathic pain being extensively researched, underlying causes remain elusive. Resent evidence from patient and rodent studies have indicated a prominent inflammatory cell component in the peripheral sensory nervous system in effected areas post chemotherapeutic treatment. This is accompanied by modulation of auxiliary cells of the dorsal root ganglia sensory neurons such as activation of satellite glia and capillary dysfunction. The presence of a neuroinflammatory component was supported by transcriptomic analysis of dorsal root ganglia taken from mice treated with common chemotherapy agents. With key inflammatory mediators identified, having potent immunoregulatory effects that directly influences nociception. We aim to evaluate the current understanding of these immune-neuronal interactions across different cancer therapy drug classes. In the belief this may lead to better pain management approaches for cancer survivors.

Item Type: Journal article
Publication Title: Frontiers in Pharmacology
Creators: Valentine, T., Hardowar, L., Elphick-Ross, J., Hulse, R.P. and Paul-Clark, M.
Publisher: Frontiers Media SA
Date: 22 June 2022
Volume: 13
ISSN: 1663-9812
Rights: © 2022 Valentine, Hardowar, Elphick-Ross, Hulse and Paul-Clark. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 30 Jun 2022 10:18
Last Modified: 30 Jun 2022 10:18

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