Physiological roles of carnosine in myocardial function and health

Creighton, J.V. ORCID: 0000-0002-5521-7392, de Souza Gonçalves, L., Artioli, G.G., Tan, D., Elliott-Sale, K.J. ORCID: 0000-0003-1122-5099, Turner, M.D. ORCID: 0000-0001-7175-1053, Doig, C.L. ORCID: 0000-0001-9694-4230 and Sale, C. ORCID: 0000-0002-5816-4169, 2022. Physiological roles of carnosine in myocardial function and health. Advances in Nutrition. ISSN 2156-5376

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Abstract

Carnosine is a pleiotropic histidine-containing dipeptide synthesised from beta-alanine and L-histidine, with the intact dipeptide and constituent amino acids being available from the diet. The therapeutic application of carnosine in myocardial tissue is promising, with carnosine playing a potentially beneficial role in both healthy and diseased myocardial models. This narrative review discusses the role of carnosine in myocardial function and health, including an overview of the metabolic pathway of carnosine in the myocardial tissue, the roles carnosine may play in the myocardium, and a critical analysis of the literature, focusing upon the effect of exogenous carnosine and its precursors on myocardial function. By so doing, we aim to identify current gaps in the literature, thereby identifying considerations for future research.

Item Type:	Journal article
Publication Title:	Advances in Nutrition
Creators:	Creighton, J.V., de Souza Gonçalves, L., Artioli, G.G., Tan, D., Elliott-Sale, K.J., Turner, M.D., Doig, C.L. and Sale, C.
Publisher:	Oxford University Press
Date:	11 June 2022
ISSN:	2156-5376
Identifiers:	Number Type 10.1093/advances/nmac059 DOI 1564416 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	13 Jul 2022 08:04
Last Modified:	13 Jul 2022 08:04
URI:	https://irep.ntu.ac.uk/id/eprint/46593

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