4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives

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Arif, Z.U., Khalid, M.Y., Zolfagharian, A. and Bodaghi, M. ORCID: 0000-0002-0707-944X, 2022. 4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives. Reactive and Functional Polymers, 179: 105374. ISSN 1381-5148

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Official URL: https://doi.org/10.1016/j.reactfunctpolym.2022.105...

Abstract

4D bioprinting is the next-generation additive manufacturing-based fabrication platform employed to construct intricate, adaptive, and dynamic soft and hard tissue structures as well as biomedical devices by using stimuli-responsive materials, especially shape memory polymers (SMPs) and hydrogels, which possess desirable biomechanical characteristics. In the last few years, numerous efforts have been made by 4D printing community to develop novel stimuli-responsive polymeric materials by considering their biomedical perspective. This review presents an up-to-date overview of 4D bioprinting technology incorporating bioprinting materials, functionalities of biomaterials as well as the focused approach towards different tissue engineering and regenerative medicine (TERM) applications, including bone, cardiac, neural, cartilage, drug delivery systems, and other high-value biomedical devices. It also addresses current limitations and challenges in 4D bioprinting technology to provide a basis for foreseeable advancements for TERM applications that will prove helpful for their successful utilization in clinical settings.

Item Type:

Journal article

Publication Title:

Reactive and Functional Polymers

Creators:

Arif, Z.U., Khalid, M.Y., Zolfagharian, A. and Bodaghi, M.

Publisher:

Elsevier BV

Date:

October 2022

Volume:

179