Exploring the constituent mechanisms of hepatitis: a dynamical systems approach

Dunster, J.L., Gibbins, J.M. and Nelson, M.R. ORCID: 0000-0001-5320-2464, 2022. Exploring the constituent mechanisms of hepatitis: a dynamical systems approach. Mathematical Medicine and Biology: A Journal of the IMA. ISSN 1477-8599 (Forthcoming)

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Abstract

Hepatitis is the term used to describe inflammation in the liver. It is associated with a high rate of mortality, but the underlying disease mechanisms are not completely understood and treatment options are limited. We present a mathematical model of hepatitis that captures the complex interactions between hepatocytes (liver cells), hepatic stellate cells (cells in the liver that produce hepatitis-associated fibrosis) and the immune components that mediate inflammation. The model is in the form of a system of ordinary differential equations. We use numerical techniques and bifurcation analysis to characterise and elucidate the physiological mechanisms that dominate liver injury and its outcome to a healthy or unhealthy, chronic state. This study reveals the complex interactions between the multiple cell types and mediators involved in this complex disease and highlights potential problems in targeting inflammation in the liver therapeutically.

Item Type:	Journal article
Publication Title:	Mathematical Medicine and Biology: A Journal of the IMA
Creators:	Dunster, J.L., Gibbins, J.M. and Nelson, M.R.
Publisher:	Oxford University Press (OUP)
Date:	9 September 2022
ISSN:	1477-8599
Identifiers:	Number Type 1597852 Other
Rights:	This article has been accepted for publication in Mathematical Medicine and Biology Published by Oxford University Press.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	27 Sep 2022 14:22
Last Modified:	27 Sep 2022 14:22
URI:	https://irep.ntu.ac.uk/id/eprint/47144

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