Human serum haptoglobin is toxic to Plasmodium falciparum in vitro

IMRIE, H., FERGUSON, D. and DAY, K.P., 2004. Human serum haptoglobin is toxic to Plasmodium falciparum in vitro. Molecular and Biochemical Parasitology, 133 (1), pp. 93-98.

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Abstract

Innate immune responses are important in the control of malaria, particularly in those who have not yet mounted an effective adaptive response. Here we report that the human serum acute phase protein, haptoglobin is toxic to Plasmodium falciparum cultured in vitro. This effect is phenotype-dependent and occurs during the trophozoite phase of the asexual life cycle. We propose that the increased levels of haptoglobin seen in the acute phase response may be protective against malaria in humans.

Item Type: Journal article
Publication Title: Molecular and Biochemical Parasitology
Creators: Imrie, H., Ferguson, D. and Day, K.P.
Publisher: Elsevier
Date: 2004
Volume: 133
Number: 1
Identifiers:
NumberType
10.1016/j.molbiopara.2003.07.007DOI
Rights: Copyright © 2004 Elsevier B.V.
Divisions: Schools > School of Animal, Rural and Environmental Sciences
Depositing User: EPrints Services
Date Added: 09 Oct 2015 09:54
Last Modified: 23 Aug 2016 09:06
URI: http://irep.ntu.ac.uk/id/eprint/4765

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