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Al-Daghri, N.M., Sabico, S., Ansari, M.G.A., Abdi, S., Tripathi, G., Chrousos, G.P. and McTernan, P.G. 
ORCID: 0000-0001-9023-0261,
2022.
Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states.
Saudi Journal of Biological Sciences, 29 (6): 103276.
ISSN 1319-562X
Abstract
There are limited studies on the association of endotoxin, a potent mediator of gut-derived inflammation and telomere length (TL). We investigated (1) the influence of adiposity on endotoxin and TL amongst Saudi adults according to type 2 diabetes mellitus (T2DM) status and (2) the influence vitamin D may have on TL attrition. Anthropometric data and fasting blood samples were taken from 775 Saudi adults visiting different primary care centers in Riyadh [387 T2DM and 388 non-T2DM]. TL, derived from peripheral blood mononuclear cells, was analyzed by Quantitative real-time polymerase chain reaction and circulating endotoxin levels by Limulus Amebocyte Lysate assay. Subjects were stratified based on obesity and T2DM status. A significant lower TL was observed in the non-obese T2DM group as compared with their non-obese, non-T2DM counterparts (p = 0.002). Significant inverse associations between TL, endotoxin and endotoxin activity were observed in the cohort with obesity. Regression analysis showed that endotoxin was a significant predictor for TL in all subjects and even after stratification according to subgroups; with variances perceived in circulating TL stronger among non-T2DM obese (10%; p = 0.003) than non-T2DM non-obese (12%; p = 0.007). Also, in the non-T2DM group, TL and HDL-cholesterol predicted 29% of the variances perceived in 25(OH)D (p < 0.001). Taken together these findings show that circulating endotoxin and 25(OH)D are associated with premature biological ageing influenced by adiposity and metabolic state; suggesting future intervention studies to manipulate gut microbiome and or vitamin D levels may offer ways to mitigate premature TL attrition.
| Item Type: | Journal article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Alternative Title: | Endotoxin induced telomere length attrition | ||||||||
| Publication Title: | Saudi Journal of Biological Sciences | ||||||||
| Creators: | Al-Daghri, N.M., Sabico, S., Ansari, M.G.A., Abdi, S., Tripathi, G., Chrousos, G.P. and McTernan, P.G. | ||||||||
| Publisher: | Elsevier | ||||||||
| Date: | June 2022 | ||||||||
| Volume: | 29 | ||||||||
| Number: | 6 | ||||||||
| ISSN: | 1319-562X | ||||||||
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| Rights: | This is an open access article under the CC BY license http://creativecommons.org/licenses/by/4.0/). | ||||||||
| Divisions: | Schools > School of Science and Technology | ||||||||
| Record created by: | Jonathan Gallacher | ||||||||
| Date Added: | 16 Feb 2023 17:41 | ||||||||
| Last Modified: | 16 Feb 2023 17:41 | ||||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/48328 |
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