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Reinwald, Y. 
ORCID: 0000-0001-6733-605X, Al-Mutheffer, E.A. and El Haj, A.J.,
2023.
Donor variability of ovine bone marrow derived mesenchymal stem cell - implications for cell therapy.
International Journal of Veterinary Science and Medicine, 11 (1), pp. 23-37.
ISSN 2314-4580
Abstract
It is assumed that all species, including sheep, demonstrate significant variation between individuals including the characteristics of their bone marrow-derived mesenchymal stem cells (BM-MSCs). These differences may account for limited success in pre-clinical animal studies and may also impact on treatment strategies that are used within regenerative medicine. This study investigates variations between ovine MSCs (oMSCs) isolated from English Mule sheep donors by studying cell viability, expansion, the cells’ trilineage differentiation potential and the expression of cell surface markers. In addition to the primary objective, this article also compares various differentiation media used for the trilineage differentiation of oMSCs. In this study, a clear individual variation between the sheep donors regarding oMSCs characterization, tri-lineage differentiation potential and marker expression was effectively demonstrated. The results set out to systematically explore the ovine mesenchymal stem cell population derived from multiple donors. With this information, it is possible to start addressing the issues of personalized approaches to regenerative therapies
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | International Journal of Veterinary Science and Medicine | ||||||
| Creators: | Reinwald, Y., Al-Mutheffer, E.A. and El Haj, A.J. | ||||||
| Publisher: | Taylor & Francis | ||||||
| Date: | 2023 | ||||||
| Volume: | 11 | ||||||
| Number: | 1 | ||||||
| ISSN: | 2314-4580 | ||||||
| Identifiers: |
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| Rights: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Jonathan Gallacher | ||||||
| Date Added: | 21 Apr 2023 07:24 | ||||||
| Last Modified: | 21 Apr 2023 07:24 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/48789 |
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