Microbially produced imidazole propionate is associated with heart failure and mortality

Tools

Molinaro, A., Nemet, I., Bel Lassen, P., Chakaroun, R., Nielsen, T., Aron-Wisnewsky, J., Bergh, P.-O., Li, L., Henricsson, M., Køber, L., Isnard, R., Helft, G., Stumvoll, M., Pedersen, O., Smith, J.G., Tang, W.H.W., Clément, K., Hazen, S.L., Bäckhed, F., Alves, R., Amouyal, C., Andersson Galijatovic, E.A., Andreelli, F., Barthelemy, O., Bastard, J.-P., Batisse, J.-P., Berland, M., Bittar, R., Blüher, M., Bork, P., Bourron, O., Camus, M., Cassuto, D., Ciangura, C., Coelho, L.P., Collet, J.-P., Dumas, M.-E., Ehrlich, S.D., Engelbrechtsen, L., Fezeu, L., Forslund, S., Fromentin, S., Galan, P., Giral, P., Gøtze, J.P., Hansen, T., Hansen, T.H., Hartemann, A., Hartmann, B., Hercberg, S., Holmes, B., Holst, J.J., Hornbak, M., Hoyles, L. ORCID: 0000-0002-6418-342X, Hulot, J.-S., Jaqueminet, S., Kerneis, M., Khemis, J., Kozlowski, R., Pedersen, H.K., Kuhn, M., Mannerås-Holm, L., Marko, L., Martinez-Gili Robin Massey, L., Maziers, N., Medina-Stamminger, J., Moitinho-Silva, L., Montalescot, G., Moutel, S., Neves, A.L., Olanipekun, M., Oppert, J.-M., Poitou, C., Pousset, F., Pouzoulet, L., Rouault, C., Silvain, J. and Vestergaard, H., 2023. Microbially produced imidazole propionate is associated with heart failure and mortality. JACC: Heart Failure, 11 (7), pp. 810-821. ISSN 2213-1779

Full text not available from this repository.

Official URL: https://doi.org/10.1016/j.jchf.2023.03.008

Abstract

Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure.

Objectives: The authors aimed to explore whether ImP is associated with heart failure and mortality.

Methods: ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression analyses were performed to delineate the impact of ImP on 5-year mortality in the North American cohort, independent of other covariates.

Results: ImP is independently associated with reduced ejection fraction and heart failure in both cohorts, even after adjusting for traditional risk factors. Elevated ImP was a significant independent predictor of 5-year mortality (for the highest quartile, adjusted HR: 1.85 [95% CI: 1.20-2.88]; P < 0.01).

Conclusions: The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival.

Item Type:

Journal article

Publication Title:

JACC: Heart Failure

Creators:

Molinaro, A., Nemet, I., Bel Lassen, P., Chakaroun, R., Nielsen, T., Aron-Wisnewsky, J., Bergh, P.-O., Li, L., Henricsson, M., Køber, L., Isnard, R., Helft, G., Stumvoll, M., Pedersen, O., Smith, J.G., Tang, W.H.W., Clément, K., Hazen, S.L., Bäckhed, F., Alves, R., Amouyal, C., Andersson Galijatovic, E.A., Andreelli, F., Barthelemy, O., Bastard, J.-P., Batisse, J.-P., Berland, M., Bittar, R., Blüher, M., Bork, P., Bourron, O., Camus, M., Cassuto, D., Ciangura, C., Coelho, L.P., Collet, J.-P., Dumas, M.-E., Ehrlich, S.D., Engelbrechtsen, L., Fezeu, L., Forslund, S., Fromentin, S., Galan, P., Giral, P., Gøtze, J.P., Hansen, T., Hansen, T.H., Hartemann, A., Hartmann, B., Hercberg, S., Holmes, B., Holst, J.J., Hornbak, M., Hoyles, L., Hulot, J.-S., Jaqueminet, S., Kerneis, M., Khemis, J., Kozlowski, R., Pedersen, H.K., Kuhn, M., Mannerås-Holm, L., Marko, L., Martinez-Gili Robin Massey, L., Maziers, N., Medina-Stamminger, J., Moitinho-Silva, L., Montalescot, G., Moutel, S., Neves, A.L., Olanipekun, M., Oppert, J.-M., Poitou, C., Pousset, F., Pouzoulet, L., Rouault, C., Silvain, J. and Vestergaard, H.

Publisher:

Elsevier

Date:

3 July 2023

Volume:

Number:

ISSN:

2213-1779

Identifiers: