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Arnold, E.L., Elarnaut, F. 
ORCID: 0000-0003-0189-6665, Downes, D. ORCID: 0000-0002-4886-5260, Evans, J.P.O. ORCID: 0000-0001-9831-1461, Greenwood, C. and Rogers, K.D.,
2023.
Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation.
Scientific Reports, 13 (1): 21480.
ISSN 2045-2322
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Abstract
Bone quality is commonly used to diagnose bone diseases such as osteoporosis, with many studies focusing on microarchitecture for fracture prediction. In this study a bovine distal femur was imaged using both micro-computed tomography (µCT) and tomosynthesis using focal construct geometry (FCG) for comparison of microarchitectural parameters. Six regions of interest (ROIs) were compared between the two imaging modalities, with both global and adaptive methods used to binarize the images. FCG images were downsampled to the same pixel size as the µCT images. Bone morphometrics were determined using BoneJ, for each imaging modality, binarization technique and ROI. Bone area/total area was found to have few significant differences between FCG and µCT (p < 0.05 for two of six ROIs). Fractal Dimension had only one significant difference (p < 0.05 for one of six ROIs) between µCT and downsampled FCG (where pixel size was equalized). Trabecular thickness and trabecular spacing were observed to follow trends as observed for the corresponding µCT images, although many absolute values were significantly different (p < 0.05 for between one and six ROIs depending on image types used). This study demonstrates the utility of tomosynthesis for measurement of microarchitectural morphometrics.
| Item Type: | Journal article | ||||||
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| Publication Title: | Scientific Reports | ||||||
| Creators: | Arnold, E.L., Elarnaut, F., Downes, D., Evans, J.P.O., Greenwood, C. and Rogers, K.D. | ||||||
| Publisher: | Springer Science and Business Media LLC | ||||||
| Date: | 6 December 2023 | ||||||
| Volume: | 13 | ||||||
| Number: | 1 | ||||||
| ISSN: | 2045-2322 | ||||||
| Identifiers: |
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| Rights: | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | ||||||
| Divisions: | Schools > Nottingham School of Art & Design Schools > School of Science and Technology |
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| Record created by: | Laura Ward | ||||||
| Date Added: | 08 Dec 2023 11:46 | ||||||
| Last Modified: | 08 Dec 2023 11:46 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/50497 |
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