Tools
Tools
Lithgow, H., Johnston, L., Ho, F.K., Celis-Morales, C., Cobley, J., Raastad, T., Hunter, A.M. 
ORCID: 0000-0001-7562-6145, Lees, J.S., Mark, P.B., Quinn, T.J. and Gray, S.R.,
2022.
Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study.
Trials, 23: 1026.
ISSN 1745-6215
|
Text
1898405_Hunter.pdf - Published version Download (1MB) | Preview |
Abstract
Background
Regular participation in resistance exercise is known to have broad-ranging health benefits and for this reason is prominent in the current physical activity guidelines. Recovery after such exercise is important for several populations across the age range and nutritional strategies to enhance recovery and modulate post-exercise physiological processes are widely studied, yet effective strategies remain elusive. Vitamin K2 supplementation has emerged as a potential candidate, and the aim of the current study, therefore, is to test the hypothesis that vitamin K2 supplementation can accelerate recovery, via modulation of the underlying physiological processes, following a bout of resistance exercise in young and older adults.
Methods
The current study is a two-arm randomised controlled trial which will be conducted in 80 (40 young (≤40 years) and 40 older (≥65 years)) adults to compare post-exercise recovery in those supplemented with vitamin K2 or placebo for a 12-week period. The primary outcome is muscle strength with secondary outcomes including pain-free range of motion, functional abilities, surface electromyography (sEMG) and markers of inflammation and oxidative stress.
Discussion
Ethical approval has been granted by the College of Medical Veterinary and Life Sciences Ethical Committee at the University of Glasgow (Project No 200190189) and recruitment is ongoing. Study findings will be disseminated through a presentation at scientific conferences and in scientific journals.
Trial registration
ClinicialTrials.gov NCT04676958. Prospectively registered on 21 December 2020.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Trials | ||||||
| Creators: | Lithgow, H., Johnston, L., Ho, F.K., Celis-Morales, C., Cobley, J., Raastad, T., Hunter, A.M., Lees, J.S., Mark, P.B., Quinn, T.J. and Gray, S.R. | ||||||
| Publisher: | Springer Science and Business Media LLC | ||||||
| Date: | 2022 | ||||||
| Volume: | 23 | ||||||
| ISSN: | 1745-6215 | ||||||
| Identifiers: |
|
||||||
| Rights: | © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Melissa Cornwell | ||||||
| Date Added: | 31 May 2024 08:03 | ||||||
| Last Modified: | 31 May 2024 08:03 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/51495 |
Actions (login required)
 |
Edit View |
Views
Views per month over past year
Downloads
Downloads per month over past year
