Molecular and cellular pathogenesis of melanoma initiation and progression

Regad, T. ORCID: 0000-0003-4028-6368, 2013. Molecular and cellular pathogenesis of melanoma initiation and progression. Cellular and Molecular Life Sciences, 70 (21), pp. 4055-4065. ISSN 1420-682X

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Abstract

Melanoma is a malignant tumour of melanocytes, which can spread to other organs of the body resulting in severe and/or lethal malignancies. Melanocytes are pigment producing cells found in deep layer of the epidermis and are originated from melanocytes stem cells through a cellular process called melanogenesis. Several genes, epigenetic and micro-environmental factors are involved in this process via the regulation and maintenance of the balance between melanocytes stem cells proliferation and their differentiation into melanocytes. Dysregulation of this balance through gain or loss of function of key genes implicated in the control and regulation of cell cycle progression and/or differentiation results in melanoma initiation and progression. This review aims at providing a comprehensive overview about the origin of melanocytes, the oncogenic events involved in melanocytes stem cells transformation and the mechanisms implicated in the perpetuation of melanoma malignant phenotype.

Item Type: Journal article
Publication Title: Cellular and Molecular Life Sciences
Creators: Regad, T.
Publisher: Birkhaeuser Science
Place of Publication: Basel
Date: 2013
Volume: 70
Number: 21
ISSN: 1420-682X
Identifiers:
NumberType
10.1007/s00018-013-1324-2DOI
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:02
Last Modified: 09 Jun 2017 13:17
URI: http://irep.ntu.ac.uk/id/eprint/6647

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