Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease

Vasa, M, Fichtlscherer, S, Adler, K, Aicher, A, Martin, H, Zeiher, AM and Dimmeler, S, 2001. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation, 103 (24), pp. 2885-2890. ISSN 0009-7322

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Background - Therapeutic neovascularization may constitute an important strategy to salvage tissue from critical ischemia. Circulating bone marrow–derived endothelial progenitor cells (EPCs) were shown to augment the neovascularization of ischemic tissue. In addition to lipid-lowering activity, hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) reportedly promote the neovascularization of ischemic tissue in normocholesterolemic animals. Methods and Results - Fifteen patients with angiographically documented stable coronary artery disease (CAD) were prospectively treated with 40 mg of atorvastatin per day for 4 weeks. Before and weekly after the initiation of statin therapy, EPCs were isolated from peripheral blood and counted. In addition, the number of hematopoietic precursor cells positive for CD34, CD133, and CD34/kinase insert domain receptor was analyzed. Statin treatment of patients with stable CAD was associated with an '1.5-fold increase in the number of circulating EPCs by 1 week after initiation of treatment; this was followed by sustained increased levels to '3-fold throughout the 4-week study period. Moreover, the number of CD34/kinase insert domain receptor–positive hematopoietic progenitor cells was significantly augmented after 4 weeks of therapy. Atorvastatin treatment increased the further functional activity of EPCs, as assessed by their migratory capacity.

Item Type: Journal article
Publication Title: Circulation
Creators: Vasa, M., Fichtlscherer, S., Adler, K., Aicher, A., Martin, H., Zeiher, A.M. and Dimmeler, S.
Publisher: American Heart Association
Date: 2001
Volume: 103
Number: 24
ISSN: 0009-7322
Divisions: Schools > School of Science and Technology
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:04
Last Modified: 23 Aug 2016 09:07

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