Frontal lobe volumes in schizophrenia: effects of stage and duration of illness

Premkumar, P. ORCID: 0000-0003-1934-6741, Kumari, V., Corr, P.J., Fannon, D. and Sharma, T., 2006. Frontal lobe volumes in schizophrenia: effects of stage and duration of illness. Journal of Psychiatric Research, 40 (7), pp. 627-637.

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Abstract

While the changes in the volume of the temporal lobe and its sub-regions over the course of illness have been studied in patients with schizophrenia, few studies have examined changes in the frontal lobe between the first episode and the chronic stage. In this study, we focussed on the effect of illness stage and duration of illness on the volume of frontal lobe regions, though we examined several other regions to establish the specificity of any effects observed for this region. We compared the volumes of brain regions among 34 first-episode schizophrenia patients, 49 chronic schizophrenia patients, 18 healthy controls matched, on average, to the first-episode patients and 21 healthy controls matched, on average, to the chronic patients. Logarithmic regression analyses examined the relationships between the duration of illness and the brain regional volumes in the patient group. The results showed that chronic patients had smaller prefrontal cortical grey matter volumes, but larger premotor cortical volumes compared to first-episode patients and matched healthy controls; they also had smaller parieto-occipital grey matter volumes and larger putamen and lateral ventricles. There was a significant exponential relation between the duration of illness and the volumes of these regions. The exponential relation suggests that the prefrontal cortex, premotor cortex, parieto-occipital cortex and putamen are susceptible to change as the disorder persists.

Item Type: Journal article
Publication Title: Journal of Psychiatric Research
Creators: Premkumar, P., Kumari, V., Corr, P.J., Fannon, D. and Sharma, T.
Publisher: Elsevier (not including Cell Press)
Date: 2006
Volume: 40
Number: 7
Identifiers:
NumberType
10.1016/j.jpsychires.2006.05.009DOI
Rights: Copyright © 2006 Elsevier Ltd. All rights reserved.
Divisions: Schools > School of Social Sciences
Depositing User: EPrints Services
Date Added: 09 Oct 2015 10:14
Last Modified: 09 Jun 2017 13:22
URI: http://irep.ntu.ac.uk/id/eprint/9787

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