A role for the CAMKK pathway in visual object recognition memory

Tinsley, C.J. ORCID: 0000-0002-9369-443X, Narduzzo, K.E., Brown, M.W. and Warburton, E.C., 2012. A role for the CAMKK pathway in visual object recognition memory. Hippocampus, 22 (3), pp. 466-476. ISSN 1098-1063

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The role of the CAMKK pathway in object recognition memory was investigated. Rats’ performance in a preferential object recognition test was examined after local infusion into the perirhinal cortex of the CAMKK inhibitor STO-609. STO-609 infused either before or immediately after acquisition impaired memory tested after a 24h but not a 20min delay. Memory was not impaired when STO-609 was infused 20min after acquisition. The expression of two downstream reaction products of CAMKK was measured by immunohistochemical staining for phospho-CAMKIThr177 and phospho-CAMKIVThr196 at 10, 40, 70 and 100 min following the viewing of novel and familiar images of objects. Processing familiar images resulted in more pCAMKI stained neurons in the perirhinal cortex than processing novel images at the 10min and 40min delays. Perirhinal neuronal counts for pCAMKIV were lower than for pCAMKI and no differential effects of processing novel and familiar images were found for pCAMKIV. Prior infusion of STO-609 caused a reduction in pCAMKI stained neurons in response to viewing either novel or familiar images, consistent with its role as an inhibitor of CAMKK. The results establish that the CAMKK pathway within the perirhinal cortex is important for the consolidation of object recognition memory. The immunohistochemical imaging for pCAMKI indicated that CAMKI might be involved in reconsolidation mechanisms for familiar stimuli in addition to consolidation mechanisms for novel stimuli. The activation of pCAMKI after acquisition is earlier than previously reported for pCAMKII. In contrast to CAMKI and CAMKII, CAMKIV appears to be unimportant for perirhinal recognition memory processes.

Item Type: Journal article
Alternative Title: Working title: CAMKK pathway and recognition memory
Publication Title: Hippocampus
Creators: Tinsley, C.J., Narduzzo, K.E., Brown, M.W. and Warburton, E.C.
Publisher: Wiley-Blackwell
Date: 2012
Volume: 22
Number: 3
ISSN: 1098-1063
Rights: © 2011 Wiley Periodicals, Inc.
The definitive version is available at www3.interscience.wiley.com.
Divisions: Schools > School of Science and Technology
Record created by: EPrints Services
Date Added: 09 Oct 2015 10:42
Last Modified: 09 Jun 2017 13:36
URI: https://irep.ntu.ac.uk/id/eprint/16836

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