'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution

McNally, A. ORCID: 0000-0002-3099-630X, Thomson, N.R., Reuter, S. and Wren, B.W., 2016. 'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution. Nature Reviews Microbiology, 14 (3), pp. 177-190. ISSN 1740-1526

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In the study of molecular microbiology and bacterial genetics, pathogenic species of the Yersinia genus have been pillars for research aimed at understanding how bacteria evolve into mammalian pathogens. The advent of large-scale population genomic studies has hugely accelerated progress in this field, and the pathogenic Yersinia species have re-emerged as model organisms to help shape our understanding of the evolutionary processes involved in pathogenesis. In this review, we highlight how microbial genomic studies of the yersiniae have revealed distinct features marking the evolutionary path towards pathogenesis, which are changing our understanding of pathogen evolution. As these features are also found in the genomes of other members of the Enterobacteriaceae, they provide a blueprint for the evolution of enteropathogenic bacteria.

Item Type: Journal article
Alternative Title: 'Add, stir and reduce’: the Yersiniae as model bacteria for the evolution of mammalian pathogens [running title]
Publication Title: Nature Reviews Microbiology
Creators: McNally, A., Thomson, N.R., Reuter, S. and Wren, B.W.
Publisher: Nature Pubishing Group
Date: 2016
Volume: 14
Number: 3
ISSN: 1740-1526
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 17 Feb 2016 14:29
Last Modified: 09 Jun 2017 13:59
URI: https://irep.ntu.ac.uk/id/eprint/26988

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