The importance and clinical relevance of surfaces in tissue culture

Hickman, G.J. ORCID: 0000-0002-4632-9229, Boocock, D.J. ORCID: 0000-0002-7333-3549, Pockley, A.G. ORCID: 0000-0001-9593-6431 and Perry, C.C. ORCID: 0000-0003-1517-468X, 2016. The importance and clinical relevance of surfaces in tissue culture. ACS Biomaterials Science & Engineering, 2 (2), pp. 152-164. ISSN 2373-9878

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Cell and tissue culture has evolved from the use of simple glassware for the propagation of cells and tissues into a comprehensive platform for interrogating complex biological systems, directing cell fate and deriving products with clinical and therapeutic value. However, despite significant advances, current in vitro culture approaches remain limited in their capacity to model the clinical/biological complexities of disease, in part at least due to the deficiencies of existing culture materials. The challenge is therefore to identify innovative materials-based solutions that have greater control over cells in vitro, while better representing biological systems in vivo. Such platforms would be suitable for biomarker discovery and tissue engineering applications. This review examines the development of tissue culture materials, advances in our understanding of cell-surface interactions and the application of this knowledge towards the development of new approaches for better examining biological events.

Item Type: Journal article
Publication Title: ACS Biomaterials Science & Engineering
Creators: Hickman, G.J., Boocock, D.J., Pockley, A.G. and Perry, C.C.
Publisher: American Chemical Society
Date: 8 February 2016
Volume: 2
Number: 2
ISSN: 2373-9878
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 05 Apr 2016 10:56
Last Modified: 06 Sep 2021 15:50

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