The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

Genua, M, Rutella, S ORCID: https://orcid.org/0000-0003-1970-7375, Correale, C and Danese, S, 2014. The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis. Journal of Translational Medicine, 12 (1), p. 293. ISSN 1479-5876

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Abstract

The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

Item Type:	Journal article
Publication Title:	Journal of Translational Medicine
Creators:	Genua, M., Rutella, S., Correale, C. and Danese, S.
Publisher:	BioMed Central Ltd.
Date:	28 October 2014
Volume:	12
Number:	1
ISSN:	1479-5876
Identifiers:	Number Type 10.1186/s12967-014-0293-z DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	12 Sep 2016 13:17
Last Modified:	09 Jun 2017 14:05
URI:	https://irep.ntu.ac.uk/id/eprint/28452

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