Towards new material biomarkers for fracture risk

Greenwood, C., Clement, J., Dicken, A. ORCID: 0000-0002-0558-3773, Evans, J.P.O. ORCID: 0000-0001-9831-1461, Lyburn, I., Martin, R.M., Rogers, K., Stone, N. and Zioupos, P., 2016. Towards new material biomarkers for fracture risk. Bone, 93, pp. 55-63. ISSN 8756-3282

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Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture. This study examines trabecular bone at both ultrastructure and microarchitectural levels to provide a detailed material view of bone, and therefore provides a more comprehensive explanation of osteoporotic fracture risk. Physicochemical characterisation obtained through X-ray diffraction and infrared analysis indicated significant differences in apatite crystal chemistry and nanostructure between fracture and non-fracture groups. Further, this study, through considering the potential correlations between the chemical biomarkers and microarchitectural properties of trabecular bone, has investigated the relationship between bone mechanical properties (e.g. fragility) and physicochemical material features.

Item Type: Journal article
Publication Title: Bone
Creators: Greenwood, C., Clement, J., Dicken, A., Evans, J.P.O., Lyburn, I., Martin, R.M., Rogers, K., Stone, N. and Zioupos, P.
Publisher: Elsevier
Date: December 2016
Volume: 93
ISSN: 8756-3282
S8756328216302526Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 03 Oct 2016 09:01
Last Modified: 31 Aug 2021 15:07

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