Mapping Depression in Schizophrenia: A Functional Magnetic Resonance Imaging Study

Kumari, V., Peters, E., Guinn, A., Fannon, D., Russell, T., Sumich, A. ORCID: 0000-0003-4333-8442, Kuipers, E., Williams, S.C.R. and Ffytche, D.H., 2016. Mapping Depression in Schizophrenia: A Functional Magnetic Resonance Imaging Study. Schizophrenia Bulletin, 42 (3), pp. 802-813. ISSN 0586-7614

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Depressive symptoms are common in schizophrenia, often
left untreated, and associated with a high relapse rate, suicidal ideation, increased mortality, reduced social adjustment and poor quality of life. The neural mechanisms underlying depression in psychosis are poorly understood. Given reports of altered brain response to negative facial affect in depressive disorders, we examined brain response to emotive facial expressions in relation to levels of depression in people with psychosis. Seventy outpatients (final N = 63) and 20 healthy participants underwent functional magnetic resonance imaging during an implicit affect processing
task involving presentation of facial expressions of fear, anger, happiness as well as neutral expressions
and a (no face) control condition. All patients completed
Beck Depression Inventory (BDI-II) and had their symptoms
assessed on the Positive and Negative Syndrome Scale (PANSS). In patients, depression (BDI-II) scores
associated positively with activation of the left thalamus, extending to the putamen-globus pallidus, insula, inferior-middle frontal and para-post-pre-central gyri during fearful expressions. Furthermore, patients with moderate-to-severe depression had significantly higher activity in these brain regions during fearful expressions relative to patients with no, minimal, or mild depression and healthy participants. The study provides first evidence of enhanced brain response to fearful facial expressions, which signal an uncertain source of threat in the environment, in patients with psychosis and a high level of self-reported depression.

Item Type: Journal article
Publication Title: Schizophrenia Bulletin
Creators: Kumari, V., Peters, E., Guinn, A., Fannon, D., Russell, T., Sumich, A., Kuipers, E., Williams, S.C.R. and Ffytche, D.H.
Publisher: Oxford University Press in association with University of Maryland School of Medicine, Maryland Psychiatric Research Center
Date: May 2016
Volume: 42
Number: 3
ISSN: 0586-7614
Rights: © The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Divisions: Schools > School of Social Sciences
Record created by: Jill Tomkinson
Date Added: 19 Oct 2016 12:52
Last Modified: 09 Jun 2017 14:07

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