Pluripotent stem cells and their dynamic niche

Reinwald, Y. ORCID: 0000-0001-6733-605X, Bratt, J. and El Haj, A.J., 2016. Pluripotent stem cells and their dynamic niche. In: M. Tomizawa, ed., Pluripotent stem cells - from the bench to the clinic. Rijeka: InTech, pp. 47-100. ISBN 9789535124726

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Cell-seeded implants are a regenerative medicine strategy that aims to replace injured tissue and restore tissue function. Pluripotent stem cells are promising cell candidates for the development of regenerative medicine therapies as they have the ability to self-renew and commit towards numerous cell types. In vivo, stem cells reside in a dynamic niche, a stem cell-specific microenvironment that possesses chemical, biological and mechanical cues, which drive the stem cell fate and renewal. The connection between
stem cells and their niche is a two-way relationship consisting of both cell–cell interac‐tion and cell–extracellular matrix (ECM) interactions. An alternative regenerative medicine approach is the manipulation of the stem cell microenvironment. Hence, novel strategies have been developed including 3D biomaterials and bioreactor technologies providing topographical, chemical and mechanical cues to recreate the stem cell niche. Understanding the mechanisms controlling stem cell fate and the dynamic nature of thestem cell niche will enable researchers to replicate this stem cell-specific microenvironment, and therefore, harness and control the valuable attributes which stem cells possess. This chapter elucidates the importance of pluripotent stem cells and their dynamic niche in regenerative medicine. It further presents novel strategies to replicate chemical, topographical and mechanical stimuli which are essential for the regulation of stem cell fate and hence tissue regeneration.

Item Type: Chapter in book
Creators: Reinwald, Y., Bratt, J. and El Haj, A.J.
Publisher: InTech
Place of Publication: Rijeka
Date: 20 July 2016
ISBN: 9789535124726
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 26 Jun 2017 13:16
Last Modified: 10 Jul 2017 10:56

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