A multivariate feature selection framework for high dimensional biomedical data classification

Alzubaidi, A. ORCID: 0000-0002-5977-564X and Cosma, G. ORCID: 0000-0002-4663-6907, 2017. A multivariate feature selection framework for high dimensional biomedical data classification. In: Proceedings of the 2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2017), Manchester, United Kingdom, 23-25 August 2017. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE), pp. 59-66. ISBN 9781467389891

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High dimensional biomedical data are becoming common in various predictive models developed for disease diagnosis and prognosis. Extracting knowledge from high dimensional data which contain a large number of features and a small sample size presents intrinsic challenges for classification models. Genetic Algorithms can be successfully adopted to efficiently search through high dimensional spaces, and multivariate classification methods can be utilized to evaluate combinations of features for constructing optimized predictive models. This paper proposes a framework which can be adopted for building prediction models for high dimensional biomedical data. The proposed framework comprises of three main phases. The feature filtering phase which filters out the noisy features; the feature selection phase which is based on multivariate machine learning techniques and the Genetic Algorithm to evaluate the filtered features and select the most informative subsets of features for achieving maximum classification performance; and the predictive modeling phase during which machine learning algorithms are trained on the selected features to construct a reliable prediction model. Experiments were conducted using four high dimensional biomedical datasets including protein and gene expression data. The results revealed optimistic performances for the multivariate selection approaches which utilize classification measurements based on implicit assumptions.

Item Type: Chapter in book
Creators: Alzubaidi, A. and Cosma, G.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Place of Publication: Piscataway, NJ
Date: 2017
ISBN: 9781467389891
Record created by: Jonathan Gallacher
Date Added: 06 Nov 2017 16:11
Last Modified: 27 Aug 2021 09:56
URI: https://irep.ntu.ac.uk/id/eprint/31986

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