Extracellular cell stress (heat shock) proteins - immune responses and disease: an overview

Pockley, A.G. ORCID: 0000-0001-9593-6431 and Henderson, B., 2018. Extracellular cell stress (heat shock) proteins - immune responses and disease: an overview. Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1738): 20160522. ISSN 0962-8436


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Extracellular cell stress proteins are highly conserved phylogenetically and have been shown to act as powerful signalling agonists and receptors for selected ligands in several different settings. They also act as immunostimulatory ‘danger signals’ for the innate and adaptive immune systems. Other studies have shown that cell stress proteins and the induction of immune reactivity to self-cell stress proteins can attenuate disease processes. Some proteins (e.g. Hsp60, Hsp70, gp96) exhibit both inflammatory and anti-inflammatory properties, depending on the context in which they encounter responding immune cells. The burgeoning literature reporting the presence of stress proteins in a range of biological fluids in healthy individuals/non-diseased settings, the association of extracellular stress protein levels with a plethora of clinical and pathological conditions and the selective expression of a membrane form of Hsp70 on cancer cells now supports the concept that extracellular cell stress proteins are involved in maintaining/regulating organismal homeostasis and in disease processes and phenotype. Cell stress proteins, therefore, form a biologically complex extracellular cell stress protein network having diverse biological, homeostatic and immunomodulatory properties, the understanding of which offers exciting opportunities for delivering novel approaches to predict, identify, diagnose, manage and treat disease.

Item Type: Journal article
Publication Title: Philosophical Transactions of the Royal Society B: Biological Sciences
Creators: Pockley, A.G. and Henderson, B.
Publisher: The Royal Society
Date: January 2018
Volume: 373
Number: 1738
ISSN: 0962-8436
29203707PubMed ID
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 07 Dec 2017 16:18
Last Modified: 30 Apr 2018 14:51
URI: https://irep.ntu.ac.uk/id/eprint/32169

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