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Abdelkader, H., Fathalla, Z., Moharram, H., Ali, T.F.S. and Pierscionek, B. 
ORCID: 0000-0002-8661-6353,
2018.
Cyclodextrin enhances corneal tolerability and reduces ocular toxicity caused by diclofenac.
Oxidative Medicine and Cellular Longevity, 2018: 5260976.
ISSN 1942-0900
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PubSub10231_Pierscionek.pdf - Published version Download (15MB) | Preview |
Abstract
With advances in refractive surgery and demand for cataract removal and lens replacement, the ocular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has increased. One of the most commonly used NSAIDs is diclofenac (Diclo). In this study, cyclodextrins (CDs), α-, β-, γ-, and HP-β-CDs, were investigated with in vitro irritation and in vivo ulceration models in rabbits to reduce Diclo toxicity. Diclo-, α-, β-, γ-, and HP-β-CD inclusion complexes were prepared and characterized and Diclo-CD complexes were evaluated for corneal permeation, red blood cell (RBCs) haemolysis, corneal opacity/permeability, and toxicity. Guest- (Diclo-) host (CD) solid inclusion complexes were formed only with β-, γ-, and HP-β-CDs. Amphipathic properties for Diclo were recorded and this surfactant-like functionality might contribute to the unwanted effects of Diclo on the surface of the eye. Contact angle and spreading coefficients were used to assess Diclo-CDs in solution. Reduction of ocular toxicity 3-fold to16-fold and comparable corneal permeability to free Diclo were recorded only with Diclo-γ-CD and Diclo-HP-β-CD complexes. These two complexes showed faster healing rates without scar formation compared with exposure to the Diclo solution and to untreated groups. This study also highlighted that Diclo-γ-CD and Diclo-HP-β-CD demonstrated fast healing without scar formation.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Oxidative Medicine and Cellular Longevity | ||||||
| Creators: | Abdelkader, H., Fathalla, Z., Moharram, H., Ali, T.F.S. and Pierscionek, B. | ||||||
| Publisher: | Hindawi | ||||||
| Date: | 2018 | ||||||
| Volume: | 2018 | ||||||
| ISSN: | 1942-0900 | ||||||
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| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 14 Feb 2018 15:19 | ||||||
| Last Modified: | 02 May 2018 14:49 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/32709 |
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