Nucleic acids, and uses thereof

Hunt, J. ORCID: 0000-0002-5168-4778 and Innes, J., 2015. Nucleic acids, and uses thereof. WO2015128651.

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Provided are siRNA molecules that are particularly efficient in their ability to reduce transcription and expression of TNF or I L-1 β in canine macrophage and synovial cells. The siRNA molecules demonstrate improved silencing of TNF or I L- 1 β as compared to siRNA molecules disclosed prior to the present invention. These properties are demonstrated in accepted experimental models of osteoarthritis, and particularly canine osteoarthritis. The siRNA molecules of the invention, may be employed in pharmaceutical compositions for use in the prevention and/or reduction of osteoarthritis in dogs. The inventors have found that encapsulation of the siRNAs in small PLGA microspheres confers surprisingly advantageous properties.

Item Type: Patent/Published patent application
Description: International application published under the Patent Cooperation Treaty (PCT). International application number: PCT/GB2015/050552. International filing date: 26.02.2015
Creators: Hunt, J. and Innes, J.
Date: 3 September 2015
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 28 Mar 2018 13:36
Last Modified: 28 Mar 2018 13:36

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