Coil conversion to β-strand induced by dimerisation

Laibe, J., Caffrey, A., Broutin, M., Guiglion, S., Pierscionek, B. ORCID: 0000-0002-8661-6353 and Nebel, J.-C., 2018. Coil conversion to β-strand induced by dimerisation. Proteins: Structure, Function, and Bioinformatics. ISSN 1097-0134

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Most molecular processes in living organisms rely on protein–protein interactions, many of which are mediated by β-sheet interfaces; this study investigates the formation of β-sheet interfaces through the conversion of coils into β-strands. Following an exhaustive search in the Protein Data Bank, the corresponding structural dimorphic fragments were extracted, characterised and analysed. Their short strand lengths and specific amino acid profiles indicate that dimorphic β-strand interfaces are likely to be less stable than standard ones and could even convert to coil interfaces if their environment changes. Moreover, the construction of a simple classifier able to discriminate between the sequences of dimorphic and standard β-strand interfaces suggests that the nature of those dimorphic sequences could be predicted, providing a novel means of identifying proteins capable of forming dimers.

Item Type: Journal article
Publication Title: Proteins: Structure, Function, and Bioinformatics
Creators: Laibe, J., Caffrey, A., Broutin, M., Guiglion, S., Pierscionek, B. and Nebel, J.-C.
Publisher: Wiley
Date: 18 July 2018
ISSN: 1097-0134
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 17 Jul 2018 07:41
Last Modified: 18 Jul 2019 03:00

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