On the way to large-scale and high-resolution brain-chip interfacing

Vassanelli, S., Mahmud, M. ORCID: 0000-0002-2037-8348, Girardi, S. and Maschietto, M., 2012. On the way to large-scale and high-resolution brain-chip interfacing. Cognitive Computation, 4 (1), pp. 71-81. ISSN 1866-9956

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Brain-chip-interfaces (BCHIs) are hybrid entities where chips and nerve cells establish a close physical interaction allowing the transfer of information in one or both directions. Typical examples are represented by multi-site-recording chips interfaced to cultured neurons, cultured/acute brain slices, or implanted “in vivo”. This paper provides an overview on recent achievements in our laboratory in the field of BCHIs leading to enhancement of signals transmission from nerve cells to chip or from chip to nerve cells with an emphasis on in vivo interfacing, either in terms of signal-to-noise ratio or of spatiotemporal resolution. Oxide-insulated chips featuring large-scale and high-resolution arrays of stimulation and recording elements are presented as a promising technology for high spatiotemporal resolution interfacing, as recently demonstrated by recordings obtained from hippocampal slices and brain cortex in implanted animals. Finally, we report on an automated tool for processing and analysis of acquired signals by BCHIs.

Item Type: Journal article
Publication Title: Cognitive Computation
Creators: Vassanelli, S., Mahmud, M., Girardi, S. and Maschietto, M.
Publisher: Springer New York
Date: 2012
Volume: 4
Number: 1
ISSN: 1866-9956
9121Publisher Item Identifier
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 24 Jul 2018 08:45
Last Modified: 24 Jul 2018 08:45
URI: https://irep.ntu.ac.uk/id/eprint/34143

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