Differential modulation of excitatory and inhibitory neurons during periodic stimulation

Mahmud, M. ORCID: 0000-0002-2037-8348 and Vassanelli, S., 2016. Differential modulation of excitatory and inhibitory neurons during periodic stimulation. Frontiers in Neuroscience, 10: 62. ISSN 1662-453X

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Non-invasive transcranial neuronal stimulation, in addition to deep brain stimulation, is seen as a promising therapeutic and diagnostic approach for an increasing number of neurological diseases such as epilepsy, cluster headaches, depression, specific type of blindness, and other central nervous system disfunctions. Improving its effectiveness and widening its range of use may strongly rely on development of proper stimulation protocols that are tailored to specific brain circuits and that are based on a deep knowledge of different neuron types response to stimulation. To this aim, we have performed a simulation study on the behavior of excitatory and inhibitory neurons subject to sinusoidal stimulation. Due to the intrinsic difference in membrane conductance properties of excitatory and inhibitory neurons, we show that their firing is differentially modulated by the wave parameters. We analyzed the behavior of the two neuronal types for a broad range of stimulus frequency and amplitude and demonstrated that, within a small-world network prototype, parameters tuning allow for a selective enhancement or suppression of the excitation/inhibition ratio.

Item Type: Journal article
Publication Title: Frontiers in Neuroscience
Creators: Mahmud, M. and Vassanelli, S.
Publisher: Frontiers Research Foundation
Date: 25 February 2016
Volume: 10
ISSN: 1662-453X
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 24 Jul 2018 08:58
Last Modified: 24 Jul 2018 08:58
URI: https://irep.ntu.ac.uk/id/eprint/34146

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