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Dolan, E., Saunders, B., Dantas, W.S., Murai, I.H., Roschel, H., Artioli, G.G. 
ORCID: 0000-0001-8463-2213, Harris, R., Bicudo, J.E.P.W., Sale, C. ORCID: 0000-0002-5816-4169 and Gualano, B.,
2018.
A comparative study of hummingbirds and chickens provides mechanistic insight on the histidine containing dipeptide role in skeletal muscle metabolism.
Scientific Reports, 8 (1): 14788.
ISSN 2045-2322
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Abstract
Histidine containing dipeptides (HCDs) have numerous ergogenic and therapeutic properties, but their primary role in skeletal muscle remains unclear. Potential functions include pH regulation, protection against reactive oxygen/nitrogen species, or Ca2+ regulation. In recognition of the challenge of isolating physiological processes in-vivo, we employed a comparative physiology approach to investigate the primary mechanism of HCD action in skeletal muscle. We selected two avian species (i.e., hummingbirds and chickens), who represented the extremes of the physiological processes in which HCDs are likely to function. Our findings indicate that HCDs are non-essential to the development of highly oxidative and contractile muscle, given their very low content in hummingbird skeletal tissue. In contrast, their abundance in the glycolytic chicken muscle, indicate that they are important in anaerobic bioenergetics as pH regulators. This evidence provides new insights on the HCD role in skeletal muscle, which could inform widespread interventions, from health to elite performance.
| Item Type: | Journal article | ||||||
|---|---|---|---|---|---|---|---|
| Publication Title: | Scientific Reports | ||||||
| Creators: | Dolan, E., Saunders, B., Dantas, W.S., Murai, I.H., Roschel, H., Artioli, G.G., Harris, R., Bicudo, J.E.P.W., Sale, C. and Gualano, B. | ||||||
| Publisher: | Nature Publishing Group | ||||||
| Date: | 2018 | ||||||
| Volume: | 8 | ||||||
| Number: | 1 | ||||||
| ISSN: | 2045-2322 | ||||||
| Identifiers: |
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| Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | ||||||
| Divisions: | Schools > School of Science and Technology | ||||||
| Record created by: | Linda Sullivan | ||||||
| Date Added: | 25 Oct 2018 10:44 | ||||||
| Last Modified: | 25 Oct 2018 10:44 | ||||||
| URI: | https://irep.ntu.ac.uk/id/eprint/34734 |
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