Type V secretion systems: an overview of passenger domain functions

Meuskens, I., Saragliadis, A., Leo, J.C. ORCID: 0000-0002-7066-7527 and Linke, D., 2019. Type V secretion systems: an overview of passenger domain functions. Frontiers in Microbiology, 10: 1163. ISSN 1664-302X

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Bacteria secrete proteins for different purposes such as communication, virulence functions, adhesion to surfaces, nutrient acquisition, or growth inhibition of competing bacteria. For secretion of proteins, Gram-negative bacteria have evolved different secretion systems, classified as secretion systems I through IX to date. While some of these systems consist of multiple proteins building a complex spanning the cell envelope, the type V secretion system, the subject of this review, is rather minimal. Proteins of the Type V secretion system are often called autotransporters (ATs). In the simplest case, a type V secretion system consists of only one polypeptide chain with a β-barrel translocator domain in the membrane, and an extracellular passenger or effector region. Depending on the exact domain architecture of the protein, type V secretion systems can be further separated into sub-groups termed type Va through e, and possibly another recently identified subtype termed Vf. While this classification works well when it comes to the architecture of the proteins, this is not the case for the function(s) of the secreted passenger. In this review, we will give an overview of the functions of the passengers of the different AT classes, shedding more light on the variety of functions carried out by type V secretion systems.

Item Type: Journal article
Publication Title: Frontiers in Microbiology
Creators: Meuskens, I., Saragliadis, A., Leo, J.C. and Linke, D.
Publisher: Frontiers Research Foundation
Date: 2019
Volume: 10
ISSN: 1664-302X
Rights: Copyright © 2019 Meuskens, Saragliadis, Leo and Linke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 18 Jun 2019 15:42
Last Modified: 25 Jun 2019 12:57
URI: https://irep.ntu.ac.uk/id/eprint/36847

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