Bacterial autoaggregation

Trunk, T., Khalil, H.S. and Leo, J.C. ORCID: 0000-0002-7066-7527, 2018. Bacterial autoaggregation. AIMS Microbiology, 4 (1), pp. 140-164. ISSN 2471-1888

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Many bacteria, both environmental and pathogenic, exhibit the property of autoaggregation. In autoaggregation (sometimes also called autoagglutination or flocculation), bacteria of the same type form multicellular clumps that eventually settle at the bottom of culture tubes. Autoaggregation is generally mediated by self-recognising surface structures, such as proteins and exopolysaccharides, which we term collectively as autoagglutinins. Although a widespread phenomenon, in most cases the function of autoaggregation is poorly understood, though there is evidence to show that aggregating bacteria are protected from environmental stresses or host responses. Autoaggregation is also often among the first steps in forming biofilms. Here, we review the current knowledge on autoaggregation, the role of autoaggregation in biofilm formation and pathogenesis, and molecular mechanisms leading to aggregation using specific examples.

Item Type: Journal article
Publication Title: AIMS Microbiology
Creators: Trunk, T., Khalil, H.S. and Leo, J.C.
Publisher: American Institute of Mathematical Sciences (AIMS) Press
Date: 2018
Volume: 4
Number: 1
ISSN: 2471-1888
Rights: © 2018 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (
Divisions: Schools > School of Science and Technology
Record created by: Linda Sullivan
Date Added: 21 Jun 2019 08:07
Last Modified: 25 Jun 2019 13:01

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