Differentiating fragmentation pathways of cholesterol by two-dimensional Fourier transform ion cyclotron resonance mass spectrometry

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Van Agthoven, M.A., Barrow, M.P., Chiron, L., Coutouly, M.-A., Kilgour, D. ORCID: 0000-0002-3860-7532, Wootton, C.A., Wei, J., Soulby, A., Delsuc, M.-A., Rolando, C. and O'Connor, P.B., 2015. Differentiating fragmentation pathways of cholesterol by two-dimensional Fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry, 26 (12), pp. 2105-2114. ISSN 1044-0305

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Official URL: https://doi.org/10.1007/s13361-015-1226-7

Abstract

Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry is a data-independent analytical method that records the fragmentation patterns of all the compounds in a sample. This study shows the implementation of atmospheric pressure photoionization with two-dimensional (2D) Fourier transform ion cyclotron resonance mass spectrometry. In the resulting 2D mass spectrum, the fragmentation patterns of the radical and protonated species from cholesterol are differentiated. This study shows the use of fragment ion lines, precursor ion lines, and neutral loss lines in the 2D mass spectrum to determine fragmentation mechanisms of known compounds and to gain information on unknown ion species in the spectrum. In concert with high resolution mass spectrometry, 2D Fourier transform ion cyclotron resonance mass spectrometry can be a useful tool for the structural analysis of small molecules.

Item Type:

Journal article

Publication Title:

Journal of the American Society for Mass Spectrometry

Creators:

Van Agthoven, M.A., Barrow, M.P., Chiron, L., Coutouly, M.-A., Kilgour, D., Wootton, C.A., Wei, J., Soulby, A., Delsuc, M.-A., Rolando, C. and O'Connor, P.B.

Publisher:

Springer

Date:

1 December 2015

Volume:

Number:

ISSN:

1044-0305

Identifiers: