Crosstalk between mast cells and adipocytes in physiologic and pathologic conditions

Elieh Ali Komi, D., Shafaghat, F. and Christian, M. ORCID: 0000-0002-1616-4179, 2020. Crosstalk between mast cells and adipocytes in physiologic and pathologic conditions. Clinical Reviews in Allergy and Immunology, 58, pp. 388-400. ISSN 1080-0549

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Excessive fatty acids and glucose uptake support the infiltration of adipose tissue (AT) by a variety of immune cells including neutrophils, pro-inflammatory M1 macrophages, and mast cells (MCs). These cells promote inflammation by releasing pro-inflammatory mediators. The involvement of MCs in AT biology is supported by their accumulation in the AT of obese individuals along with significantly higher serum levels of MC-derived tryptase. AT-resident MCs under the influence of locally derived adipokines such as leptin become activated and release pro-inflammatory cytokines including TNFα that worsens the inflammatory state. MCs support angiogenesis in AT by releasing chymase and inducing preadipocyte differentiation and also the proliferation of adipocytes through 15-deoxy-delta PGJ2/PPARγ interaction. Additionally, they contribute to the remodeling of the AT extracellular matrix (ECM) and play a role in the recruitment and activation of leukocytes. MC degranulation has been linked to brown adipocyte activation, and evidence indicates an important link between MCs and the appearance of BRITE/beige adipocytes in white AT. Cell crosstalk between MCs and AT-resident cells, mainly adipocytes and immune cells, shows that these cells play a critical role in the regulation of AT homeostasis and inflammation.

Item Type: Journal article
Publication Title: Clinical Reviews in Allergy and Immunology
Creators: Elieh Ali Komi, D., Shafaghat, F. and Christian, M.
Publisher: Springer
Date: June 2020
Volume: 58
ISSN: 1080-0549
Rights: © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
Divisions: Schools > School of Science and Technology
Record created by: Jill Tomkinson
Date Added: 13 May 2020 13:51
Last Modified: 22 Jun 2020 09:21

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