Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management

Comont, D, Lowe, C, Hull, R, Crook, L, Hicks, H ORCID: https://orcid.org/0000-0003-1325-2293, Onkokesung, N, Beffa, R, Childs, DZ, Edwards, R, Freckleton, RP and Neve, P, 2020. Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management. Nature Communications, 11 (1): 3086. ISSN 2041-1723

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Abstract

Intense selection by pesticides and antibiotics has resulted in a global epidemic of evolved resistance. In agriculture and medicine, using mixtures of compounds from different classes is widely accepted as optimal resistance management. However, this strategy may promote the evolution of more generalist resistance mechanisms. Here we test this hypothesis at a national-scale in an economically important agricultural weed: blackgrass (Alopecurus myosuroides), for which herbicide resistance is a major economic issue. Our results reveal that greater use of herbicide mixtures is associated with lower levels of specialist resistance mechanisms, but higher levels of a generalist mechanism implicated in enhanced metabolism of herbicides with diverse modes of action. Our results indicate a potential evolutionary trade-off in resistance management, whereby attempts to reduce selection for specialist resistance traits may promote the evolution of generalist resistance. We contend that where specialist and generalist resistance mechanisms co-occur, similar trade-offs will be evident, calling into question the ubiquity of resistance management based on mixtures and combination therapies.

Item Type:	Journal article
Publication Title:	Nature Communications
Creators:	Comont, D., Lowe, C., Hull, R., Crook, L., Hicks, H., Onkokesung, N., Beffa, R., Childs, D.Z., Edwards, R., Freckleton, R.P. and Neve, P.
Publisher:	Nature Research (part of Springer Nature)
Date:	2020
Volume:	11
Number:	1
ISSN:	2041-1723
Identifiers:	Number Type 10.1038/s41467-020-16896-0 DOI 1332423 Other
Rights:	© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	Jill Tomkinson
Date Added:	16 Jun 2020 13:14
Last Modified:	31 May 2021 15:19
URI:	https://irep.ntu.ac.uk/id/eprint/40004

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