Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review

Hepsomali, P., Groeger, J.A. ORCID: 0000-0002-3582-1058, Nishihira, J. and Scholey, A., 2020. Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review. Frontiers in Neuroscience, 14: 923. ISSN 1662-4548

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Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role of natural and/or biosynthetic oral GABA intake on stress and sleep are mixed. We performed a systematic review to examine whether natural and/or biosynthetic oral GABA intake has an effect on stress and sleep. We systematically searched on PubMed database for studies published up to February 2020 following PRISMA guidelines. Only placebo-controlled human trials that assessed stress, sleep, and related psychophysiological outcomes as a response to natural GABA (i.e., GABA that is present naturally in foods) or biosynthetic GABA (i.e., GABA that is produced via fermentation) intake were included. Fourteen studies met the criteria and were included in the systematic review. Although more studies are needed before any inferences can be made about the efficacy of oral GABA consumption on stress and sleep, results show that there is limited evidence for stress and very limited evidence for sleep benefits of oral GABA intake.

Item Type: Journal article
Publication Title: Frontiers in Neuroscience
Creators: Hepsomali, P., Groeger, J.A., Nishihira, J. and Scholey, A.
Publisher: Frontiers Media
Date: September 2020
Volume: 14
ISSN: 1662-4548
Rights: Copyright © 2020 Hepsomali, Groeger, Nishihira and Scholey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions: Schools > School of Social Sciences
Record created by: Linda Sullivan
Date Added: 28 Oct 2020 14:44
Last Modified: 31 May 2021 15:14
URI: https://irep.ntu.ac.uk/id/eprint/41426

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