Sleep quality is associated with vitamin B12 status in female Arab students

Al-Musharaf, S., Alabdulaaly, A., Bin Mujalli, H., Alshehri, H., Alajaji, H., Bogis, R., Alnafisah, R., Alfehaid, S., Alhodaib, H., Murphy, A.M. ORCID: 0000-0001-5554-1558, Danish Hussain, S., Sabico, S., McTernan, P. ORCID: 0000-0001-9023-0261 and Al-Daghri, N., 2021. Sleep quality is associated with vitamin B12 status in female Arab students. International Journal of Environmental Research and Public Health, 18 (9): 4548. ISSN 1661-7827

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Abstract

Studies have explored how vitamin B12 status affects sleep among elders and children, but this remains to be investigated among young adults. We used the Pittsburgh Sleep Quality Index (PSQI) to assess the association between serum vitamin B12 and sleep among female college students in Saudi Arabia. In this cross-sectional study, we enrolled 355 participants (age (years), 20.7 ± 1.5; body mass index, 23.6 kg/m2 ± 5.2) at King Saud University, Riyadh, Saudi Arabia. Fasting blood samples were analyzed regarding the serum vitamin B12 and blood lipids. Anthropometric, socio-demographic, clinical history, stress, physical activity, and dietary data were collected. We assessed the sleep statuses of the participants using the PSQI. Around 72% of the participants were “poor” sleepers (PSQI > 5). Subgroup analysis within the tertiles showed that participants with higher vitamin B12 in the second and third tertiles reported better scores for sleep quality (B ± SE = −12.7 ± 5.6, p = 0.03; B ± SE = −32.7 ± 16.4, p = 0.05, respectively) and also reported a lower use of sleep medication (B ± SE = −21.2 ± 9.9, p = 0.03, in the second tertile only), after adjusting for the waist–hip ratio and stress. However, sleep was not found to be directly associated with either serum vitamin B12 or dietary vitamin B12. In conclusion, the serum vitamin B12 results show that the participants with higher vitamin B12 in the second and third tertiles reported better scores on the sleep quality scale and a lower use of sleep medication. However, no such associations were observed with the overall PSQI. More studies with larger sample sizes are needed to establish a direct relationship between sleep and vitamin B12.

Item Type: Journal article
Publication Title: International Journal of Environmental Research and Public Health
Creators: Al-Musharaf, S., Alabdulaaly, A., Bin Mujalli, H., Alshehri, H., Alajaji, H., Bogis, R., Alnafisah, R., Alfehaid, S., Alhodaib, H., Murphy, A.M., Danish Hussain, S., Sabico, S., McTernan, P. and Al-Daghri, N.
Publisher: MDPI
Date: 25 April 2021
Volume: 18
Number: 9
ISSN: 1661-7827
Identifiers:
NumberType
10.3390/ijerph18094548DOI
1434788Other
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Divisions: Schools > School of Science and Technology
Record created by: Laura Ward
Date Added: 29 Apr 2021 13:17
Last Modified: 31 May 2021 15:03
Related URLs:
URI: http://irep.ntu.ac.uk/id/eprint/42779

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